Clinical Neuromuscular Center and Neurogenetics

Introduction

The research group Neuromuscular Diseases and Neurogenetics is integrated into the Clinical Neuromuscular Center of the Clinic for Neurology at the University Hospital Zurich (USZ).

One focus of the research group is the investigation of the influence of physical training on the course of neuromuscular and neurodegenerative diseases as well as the clinical, pathological and genetic characterization of patients with genetically determined neuromuscular and neurodegenerative diseases, especially Huntington's disease (Prof. Dr. H Jung).  Concerning patient care, there is a well-established collaboration with the University Children's Hospital Zurich and the Department of Pulmology of the USZ under the roof of the Clinical Neuromuscular Center Zurich, a regional center in the network Myosuisse. Around 1,600 consultations take place per year, covering the whole spectrum of neuromuscular disorders (contact: muskel@usz.ch). There are regular interdisciplinary consultations for patients with neuromuscular breathing problems together with the Department of Pulmology USZ and a transition consultation for juvenile neuromuscular patients on the threshold of adulthood at the University Children's Clinic. At the electroneuromyography unit, about 1500 examinations are performed per year.

The research group Neuromuscular Disorders and Neurogenetics is supported by the SNSF and the European Huntington Disease Network (EHDN).
 
The focus of translational research projects on Inflammatory Neuromuscular Diseases (PD Dr. Schreiner) is to gain a better understanding of disease mechanisms of myasthenia gravis or inflammatory neuropathies by analyzing immune and glial cell markers (NeuroMyoCyTOF project). To this end, we work closely together with other clinics at the University Hospital Zurich (USZ), such as the Dep. of Thoracic Surgery, as well as the University of Zurich (UZH, Inst. of Exp. Immunology, Group Becher, F. Ingelfinger) and the Federal Institute of Technology (ETH, Inst. of Microbiology, Group Latorre). There are also international collaborations (e.g. with University College London).

The research projects are among others supported by the Swiss Foundation for Research on Muscle Diseases.

Special consultation hours for inflammatory neuromuscular diseases aim to optimize interprofessional and interdisciplinary diagnosis and care of patients with myasthenia gravis and other immune-mediated neuromuscular diseases.  Under certain circumstances, these disorders can be triggered by the increased use of novel tumor drugs, so-called checkpoint inhibitors. To ensure the best possible care, there is a close exchange with colleagues from the Dep. Of Neuroophthalmology, the Clinical Immunology, Rheumatology, Pathology and Thoracic Surgery at the USZ. Neuromuscular imaging techniques such as high-resolution ultrasound are implemented.


Address 

Center of Neuromuscular Disorders
Department of Neurology
University Hospital Zurich
Frauenklinikstrasse 26
8091 Zurich

Contact:
Tel. +41 44 255 55 20
Fax +41 44 255 43 80
muskel@usz.ch


Team

Team Leader

Prof. Dr. Hans H. Jung
Leading Senior Physician
T: +41 44 255 55 20
hans.jung@usz.ch

Deputy and Team Leader Inflammatory Neuromuscular Diseases

PD Dr. Bettina Schreiner
Attending Physician
Tel.: +41 44 255 55 20
bettina.schreiner@usz.ch

Attending Physician

Dr. Violeta Mihaylova
Tel.: +41 44 255 55 20
violeta.mihaylova@usz.ch

Coordinator Clinical Neuromuscular Center

Alexandra West
Koordinatorin / Coordinator
Tel.: +41 44 255 55 20
muskel@usz.ch


Scientific focus

DOMINO Study Multi-Domain Lifestyle Targets for Improving Prognosis in Huntington’s Disease
Team K. Renerts, H.H. Jung, V. Mihaylova
Project leader: H.H. Jung
SNF

ENROLL Study in Huntington's Disease
Team K. Renerts, H.H. Jung, V. Mihaylova
Project leader: H.H. Jung
EHDN

Inflammatory Neuromuscular Diseases (Project leader: PD Dr. Schreiner):
See: fsrmm - Myasthenie Projekt; fsrmm - GBS Projekt (Dr. Latorre)


Publications

Prof. H. H. Jung: jung hh zurich - Search Results - PubMed (nih.gov)
PD Dr. Bettina Schreiner: https://scholar.google.ch/citations?hl=de&user=6o9PUhUAAAAJ




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