Neuromuscular Center Zurich

Welcome to the Center of Neuromuscular Disorders Zurich, a collaborative project of the University Hospital and University Children’s Hospital Zurich. Our aim is to provide the best possible diagnosis, treatment and care of children and adults with neuromuscular disorders by means of an intensive, interdisciplinary collaboration.

Neuromuscular Disorders

Neuromuscular disorders may affect patients in every age, their course is mostly progressive, and they may be associated with physical impairment and even a reduced life span.  Apart from the muscles (myopathy), neuromuscular disorders may affect the motor nerves (motoneuron disorders and neuropathies) or the neuromuscular transmission from nerve to muscle (myasthenic syndromes). Patients with neuromuscular disorders may suffer from weakness, palsies and muscle wasting, but may also experience pain, sensory disturbances, breathing, speech and swallowing problems.

Several neuromuscular disorders are congenital or genetically determined. The most frequent entity in childhood is Duchenne muscular dystrophy (DMD), affecting one of 3500 boys. DMD manifests in early childhood, usually with subtle leg weakness which progresses to other muscle groups with increasing age. Other genetically determined neuromuscular disorders may manifest in infancy but also later in life, such as congenital myopathies, limb girdle muscular dystrophies or myotonic dystrophy.

Other neuromuscular disorders are caused by inflammation, infections or metabolic alterations. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of motoneurons in the cerebral cortex and the spinal cord, leading to a neurogenic muscle atrophy but also spasticity. Additional neuromuscular disorders include chronic inflammations of muscles (polymyositis) or peripheral nerves (chronic inflammatory demyelinating polyneuropathy; CIDP).


Referral

A referral to the neuromuscular consultation can be made by letter, fax (+41 44 255 43 80) or secure mail (muskel@usz.ch). There are regular interdisciplinary consultations for patients with neuromuscular breathing problems together with the Department of Pulmology USZ as well as a transitional consultation for juvenile neuromuscular patients at the University Children Hospital Zürich.

Additional Examinations

If necessary, we will perform additional examinations such as electroneurography (ENG), electromyography (EMG), examinations of the neuromuscular transmission (repetitive stimulation, stimulated single fiber EMG), motor evoked potentials (MEP), electrophysiological examination of autonomic functions (sympathetic sudomotor skin responses, R-R-interval variation), metabolic examination including metabolic function tests as well as muscle and nerve biopsies (Link ENMG).

Scientific Focus

The scientific focus of the research group is the examination of the effects of physical exercise on muscle properties and course of neuromuscular and neurodegenerative disorders. One current project funded by the Swiss National Foundation (SNF) examines the effect of regular physical exercise in patients with Huntington-disease. Other clinical-scientific projects are dedicated to the clinical, pathological and genetic characterization of Swiss patients with muscle dystrophies and the McLeod neuroacanthocytosis syndrome.

There are periodic clinical-pathological conferences, two times per year together as a joint meeting with other Swiss neuromuscular specialists. Neuromuscular symposia will be organized annually.

Further Information

Please refer to our brochure "Neuromuskuläres Zentrum Zürich" (German, PDF) for further information.

 

Team

Team Leader

Prof. Dr. med. Hans H. Jung
Senior Leading Physician Neurology
Tel. +41 44 255 55 20
Fax +41 44 255 43 80
hans.jung@usz.ch

Prof. Dr. med. Konrad Ernst Bloch
Senior Leading Physician Pneumology
Tel. +41 44 255 11 11
Fax +41 44 255 44 51
konrad.bloch@usz.ch


Office

Ursula Lombriser
Coordinator
Tel.: +41 44 255 55 20
Fax +41 44 255 43 80
muskel@usz.ch